B-Complex Plus is an exceptional combination of B vitamins, including vitamins B1, B2, B3, B5, B6, B12, biotin,
and folic acid, all of which are provided in their optimal bioavailable and functional forms.*

• Vitamin B6 (pyridoxine HCl and pyridoxal 5’ phosphate), supporting amino acid metabolism, nervous system
health, and neurotransmitter (i.e. GABA and serotonin) synthesis, which studies have reported may help
promote menstrual comfort. Furthermore, pyridoxine supports healthy red blood cells by participating in
hemoglobin synthesis and some studies indicate it supports wrist nerve comfort.*

• Vitamin B1 (thiamine HCl), processing carbohydrates, fat, and protein via its coenzyme form of thiamine
pyrophosphate (TPP). Vitamin B1 is required to form adenosine triphosphate (ATP), the key source of energy
for the body. Thiamine also promotes neural health.*

• Vitamin B2 (riboflavin and riboflavin 5’ phosphate),metabolizing nutrients and participating in electron
transport to form ATP. Riboflavin is an integral part of fatty acid catabolism or ß-oxidation and helps convert
folic acid and vitamins B6 to their active states.*

• Vitamin B3 (niacinamide and inositol hexaniacinate), supporting cardiovascular health by mediating healthy
lipid and carbohydrate metabolism.*

• Vitamin B5 (calcium pantothenate), supporting cardiovascular health. Pantothenic acid is vital in the
healthy production, transportation, and breakdown of lipids. Furthermore, this B vitamin promotes the
production of the neurotransmitter acetylcholine.*

• Vitamin B12 (methylcobalamin), supporting healthy nerve cell activity and DNA replication. Vitamin B12 is
a vital component of the methionine synthase pathway, which along with folic acid and vitamin B6
supports healthy homocysteine metabolism and S-adenosylmethionine (SAMe) production.*

• Folic acid, promoting the production of healthy DNA and chromosomes. In particular, this B vitamin is critical
for the proper neural and cellular development of the fetal central nervous system, helping to prevent neural
tube defects. In conjunction with vitamins B12 and B6, folic acid helps to support healthy homocysteine
metabolism. Additionally, this B vitamin is important for the growth and reproduction of red and white blood
cells.*†

• Biotin, acting as a coenzyme for the metabolism of fat, carbohydrates and protein.*

These B vitamins play important roles in nearly all of the physiological systems in the body. Some of the key
supportive roles include the maintenance of muscle tone in the GI tract, the functioning of the nervous system, and
the integrity of skin, hair, and the liver. Furthermore, these compounds are essential for healthy fetal neural
development, hemoglobin formation, nerve impulse transmissions, mood, hormone synthesis, and energy
metabolism.*†

Pure Encapsulations B-Complex Plus formula contains:
Vitamin B1 (thiamine HCl): synthetic
Vitamin B2 (riboflavin): corn dextrose fermentation
Niacinamide and Inositol hexaniacinate: synthetic
Vitamin B5 (calcium pantothenate): synthetic
Vitamin B6 (pyridoxal HCl): synthetic
Vitamin B12 (methylcobalamin): corn dextrose fermentation
Folic acid: synthetic
Biotin: synthetic

Vitamin C (ascorbyl palmitate) is derived from corn dextrose
fermentation and palm oil.


*These statements have not been evaluated by the Food & Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

†Women who consume healthful diets with adequate folate may reduce their risk of having a child with birth defects of the brain or spinal cord. Folate intake should not exceed 250% of the DV (1,000 mcg).