Uni-Joint^™

Support for structure and function of healthy joints

DESCRIPTION
Uni-Joint^™ Formula, provided by Douglas Laboratories^®, is a synergistic and comprehensive combination of natural ingredients, including glucosamine sulfate, bovine and shark cartilage/mucopolysaccharides, and bromelain, carefully formulated and specifically designed to ease discomfort while maintaining and restoring the structure and function of healthy joints.

FUNCTIONS
Glucosamine is a naturally occurring amino sugar found in glycosoaminoglycans (mucopolysaccharides), integral components of the proteoglycans found in joint cartilage. Proteoglycans are large carbohydrate rich structures that provide resiliency, load distribution, shock-absorbing, compressive and lubricating properties to joints and connective tissues. Dietary glucosamine serves as an immediate precursor for glycosaminoglycan synthesis, and also stimulates incorporation of other precursors into the connective tissue matrix.

The availability of glucosamine is an integral part of the synthesis of glycosaminoglycans and proteoglycans that are necessary during the constant remodeling that aging cartilage undergoes. Thus, the maintenance of healthy aging cartilage may be improved with enhanced deposition of glycosaminoglycans and proteoglycans.

Bioavailability of oral glucosamine sulfate is excellent.
It is absorbed intact, and utilized very quickly by all tissues, including connective tissues.

Glucosamine sulfate is more efficiently used for connective tissue metabolism than other glucosamine sources, such as cartilage extracts or chondroitin sulfate. Glucosamine sulfate is a well recognized, highly effective source of glucosamine for glycosaminoglycan and proteoglycan synthesis in all connective tissues, such as cartilage, ligaments, tendons, skin, and bone.

Bromelain, a protease from the pineapple plant, reduces the production of proinflammatory prostaglandins by modulating the arachidonate cascade. Its ability to help modulate normal inflammatory processes and support the discomfort associated with aging joints.

INDICATIONS
Uni-Joint^™ Formula capsules may be a useful dietary supplement for those who wish to support the structure and function of healthy joints.

FORMULA  (#82891)

Each Capsule Contains:

Glucosamine Sulfate ........................................  250.. mg

Sea Cucumber Powder ....................................  150.. mg
(Pseudocalochirus axiologus)

Shark Cartilage Powder.................................... 150.. mg

Bromelain (lower stem, pineapple plant) ......  150.... m.c.u.

Bovine Cartilage/mucopolysaccharides......      ... 50.. mg

In a base of Yucca Powder and Bilberry Extract

SUGGESTED USE
Adults take 1 capsule daily or as directed by physician.

SIDE EFFECTS
No adverse effects have been reported

STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCES
Giordano N, Nardi P, Senesi M, Palumbo F, Battisti E, Gonnelli S, Franci B, Campagna MS, Gennari C. [The efficacy and safety of glucosamine sulfate in the treatment of gonarthritis]. Clin Ter 1996;147:99-105.Gottlieb MS. Conservative management of spinal osteoarthritis with glucosamine sulfate and chiropractic treatment. J Manipulative Physiol Ther 1997;20:400-14.Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev 1998;3:27-39.Leeb BF, Petera P, Neumann K. [Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints]. Wien Med Wochenschr 1996;146:609-14.Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med 1999;164:85-91. Lopes Vaz A. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8:145-9. Lotz-Winter H. On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Planta Med 1990;56:249-53. McCarty MF. Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis. Med Hypotheses 1998;50:507-10. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469-74. Setnikar I, Cereda R, Pacini MA, Revel L. Antireactive properties of glucosamine sulfate. Arzneimittelforschung 1991;41:157-61. Shankland WE, 2nd. The effects of glucosamine and chondroitin sulfate on osteoarthritis of the TMJ: a preliminary report of 50 patients. Cranio 1998;16:230-5. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica 1982;3:157-68. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.

These statements have not been evaluated
by the Food and Drug Administration.

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