DESCRIPTION

Vitamin C Supreme from Nutrition Dynamics contain 1000 mg vitamin C with rose hips and an additional amount of bioflavonoid complex.

FUNCTIONS

Vitamin C (ascorbic acid) has numerous biological functions. Foremost, it is essential for the synthesis of collagen and glycosaminoglycans which are the building materials of all connective tissues, such as skin, blood vessels, tendons, joint cartilage and bone. Vitamin C is the required coenzyme for two groups of enzymes that catalyze the crosslinking of collagen fibers - lysyl hydroxylases and prolyl hydroxylases. As such, vitamin C is essential for normal wound healing and capillary health. It also participates in the biosynthesis of carnitine, serotonin, and certain neurotransmitters, including norepinephrine.

Vitamin C is among the most powerful antioxidants in humans and animals. It is a water-soluble, chain-breaking antioxidant that reacts directly with superoxide, hydroxyl radicals, and singlet oxygen. Laboratory studies show that vitamin C completely protects lipids in plasma and low-density lipoprotein (LDL) against atherogenic peroxidative damage. In addition, vitamin C interacts with glutathione and alpha-lipoic acid, and regenerates vitamin E. The antioxidant functions of vitamin C appear to have clinical significance in providing protection from free radical damage to the eyes, lungs, blood and the immune system.

Vitamin C is absorbed in the small intestine by a sodium-dependent transport process that is intake dependent. At normal dietary intakes of 60 to 100 mg, up to 80 or 90% of the vitamin C is absorbed. At higher intakes, absorption becomes less efficient. Absorption efficiency and vitamin C utilization may be greatly enhanced during conditions of physiological stress, such as trauma or infection.

Bioflavonoids (also called flavonoids) are a class of phytochemicals that are potent antioxidants, which scavenge many potentially damaging free radicals. Another aspect of the antioxidant properties of bioflavonoids is their synergy with vitamin C, as well as their ability to bind to metal ions, preventing these metals from catalyzing enhanced free radical production.

Many bioflavonoids support the health of the body’s circulatory system by helping maintain capillary blood flow and proper vascular permeability, integrity, and resiliency.

INDICATIONS

Natural C 1,000 mg tablets may be a useful dietary supplement for those who wish to increase their daily intake of this important antioxidant vitamin together with a bioflavonoid complex.

FORMULA  (#7920)

Each Tablet Contains:

Vitamin C......................................... 1,000. mg

    (from Rose Hips)

Bioflavonoid Complex........................... 100. mg

SUGGESTED USE

Adults take 1 tablet daily or as directed by physician.

SIDE EFFECTS

No adverse effects have been reported.

STORAGE

Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCES

Anderson JW, Gowri MS, Turner J, et al. Antioxidant supplementation effects on low-density lipoprotein oxidation for individuals with type 2 diabetes mellitus. J Am Coll Nutr 1999;18:451-61.

Ascherio A, Rimm EB, Hernan MA, et al. Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med 1999;130:963-70.

Brennan LA, Morris GM, Wasson GR, et al. The effect of vitamin C or vitamin E supplementation on basal and H2O2- induced DNA damage in human lymphocytes. Br J Nutr 2000;84:195-202.

Hamilton IM, Gilmore WS, Benzie IF, et al. Interactions between vitamins C and E in human subjects. Br J Nutr 2000;84:261-7.

Masaki KH, Losonczy KG, Izmirlian G, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000;54:1265-72.

Otsuka M, Matsuzawa M, Ha TY, et al. Contribution of a high dose of L-ascorbic acid to carnitine synthesis in guinea pigs fed high-fat diets. J Nutr Sci Vitaminol (Tokyo) 1999;45:163-71.

Schroder H, Navarro E, Tramullas A, et al. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Med 2000;21:146-50.

Simon JA, Hudes ES. Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults: the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol 1999;9:358-65.

Ushakova T, Melkonyan H, Nikonova L, et al. Modification of gene expression by dietary antioxidants in radiation- induced apoptosis of mice splenocytes. Free Radic Biol Med 1999;26:887-91.

Victor VV, Guayerbas N, Puerto M, et al. Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock. Immunopharmacology 2000;46:89-101.